Structure of PDB 6h1h Chain A

Receptor sequence
>6h1hA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGF
PDHPHRGFETVSYLLEGGSMAHEDFCGHTGKMNPGDLQWMTAGRGILHAE
MPCSEEPAHGLQLWVNLRSSEKMVEPQYQELKSEEIPKPSKDGVTVAVIS
GEALGIKSKVYTRTPTLYLDFKLDPGAKHSQPIPKGWTSFIYTISGDVYI
GPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVLIAGEPLREPVIQH
GPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
3D structure
PDB6h1h Privileged Structures and Polypharmacology within and between Protein Families.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.24: quercetin 2,3-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H56 H58 H101 E103 H53 H55 H98 E100
BS02 FJE A D43 F45 F53 H56 E103 Q115 W117 D40 F42 F50 H53 E100 Q112 W114 PDBbind-CN: -logKd/Ki=6.17,IC50=0.67uM
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0005515 protein binding
GO:0008127 quercetin 2,3-dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0007586 digestion
GO:0030099 myeloid cell differentiation
GO:0030224 monocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h1h, PDBe:6h1h, PDBj:6h1h
PDBsum6h1h
PubMed30613326
UniProtO00625|PIR_HUMAN Pirin (Gene Name=PIR)

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