Structure of PDB 6h0x Chain A

Receptor sequence
>6h0xA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKY
QTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTI
QDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK
TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIP
FNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQC
SCGEARVTFSMDAFVRILQPERYDLWKRG
3D structure
PDB6h0x Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C238 H244 C310 C312 C228 H234 C300 C302
BS02 FJB A H90 Y136 Y181 H192 E194 N202 K210 K245 H280 R316 H80 Y126 Y171 H182 E184 N192 K200 K235 H270 R306
External links
PDB RCSB:6h0x, PDBe:6h0x, PDBj:6h0x
PDBsum6h0x
PubMed
UniProtQ6B0I6|KDM4D_HUMAN Lysine-specific demethylase 4D (Gene Name=KDM4D)

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