Structure of PDB 6h0t Chain A

Receptor sequence
>6h0tA (length=514) Species: 9606 (Homo sapiens) [Search protein sequence]
SKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPG
WQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV
MIWIYGGAFLYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNY
GLRDQHMAIAWVKRNIAAFGGDPDNITLFGESAGGASVSLQTLSPYNKGL
IRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTD
PRALTLAYKYPMLHYVGFVPVIDGDFIPDDPINLYANAADIDYIAGTNNM
DGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTE
SWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFS
HPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWT
NFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFL
RYWTLTYLALPTVT
3D structure
PDB6h0t X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G107 A108 S194 A195 D320 H435
Catalytic site (residue number reindexed from 1) G107 A108 S182 A183 D301 H416
Enzyme Commision number 3.1.1.13: sterol esterase.
3.1.1.3: triacylglycerol lipase.
3.1.1.6: acetylesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H487 E489 H468 E470
BS02 ZN A D77 E78 D77 E78
BS03 ZN A D328 E388 D309 E369
BS04 ZN A H322 D434 H303 D415
BS05 ZN A G107 A195 G107 A183
External links
PDB RCSB:6h0t, PDBe:6h0t, PDBj:6h0t
PDBsum6h0t
PubMed30359675
UniProtP19835|CEL_HUMAN Bile salt-activated lipase (Gene Name=CEL)

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