Structure of PDB 6gzy Chain A

Receptor sequence
>6gzyA (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
QGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYA
KNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEP
PGCRVIEQRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEV
EELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK
3D structure
PDB6gzy Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FHH A I869 Y878 C885 H887 F888 H889 T891 S899 Q974 I12 Y21 C28 H30 F31 H32 T34 S42 Q108 PDBbind-CN: -logKd/Ki=3.40,Kd>400uM
BS02 ZN A C871 C874 C890 C893 C14 C17 C33 C36
BS03 ZN A C898 C901 H926 C930 C41 C44 H69 C73
BS04 ZN A C911 C916 H923 H925 C54 C59 H66 H68
BS05 ZN A C969 C986 C998 H1001 C103 C113 C125 H128
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6gzy, PDBe:6gzy, PDBj:6gzy
PDBsum6gzy
PubMed30657686
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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