Structure of PDB 6gzh Chain A

Receptor sequence
>6gzhA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE
GFPITALREIKILQLLKHENVVNLIEICRTKASGSIYLVFDFCEHDLAGL
LSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL
KLADFGLARAFSLAQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAG
CIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE
LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW
SDPMPSDLKG
3D structure
PDB6gzh Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
ChainA
Resolution3.17 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 N154 D167 T191
Catalytic site (residue number reindexed from 1) D136 K138 N141 D154 T175
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LCI A I25 G26 F30 A46 F103 F105 C106 D109 L156 I18 G19 F23 A39 F90 F92 C93 D96 L143 PDBbind-CN: -logKd/Ki=8.27,Kd=5.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gzh, PDBe:6gzh, PDBj:6gzh
PDBsum6gzh
PubMed30146162
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

[Back to BioLiP]