Structure of PDB 6gyr Chain A

Receptor sequence

>6gyrA (length=588) Species: 9606 (Homo sapiens)

AKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK
SPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSK
LSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSY
QNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELF
VECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLP
STRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFV
DSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVY
ISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGD
DYIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDR
LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTGNKKKPGMPNV
SNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDG
RDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD

3D structure

• PDB: 6gyr Transcription factor dimerization activates the p300 acetyltransferase.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1163 C1164 H1255 C1258	C119 C120 H211 C214
BS02	ZN	A	C1247 C1250 C1272	C203 C206 C228
BS03	ZN	A	C1177 C1183 C1201 C1204	C133 C139 C157 C160
BS04	01K	A	Y1397 L1398 S1400 R1410 T1411 Y1414 W1436 C1438 P1440 Y1446 K1456 I1457 P1458 W1466 F1467	Y353 L354 S356 R366 T367 Y370 W392 C394 P396 Y402 K412 I413 P414 W422 F423
BS05	ZN	A	H1315 C1408	H271 C364

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:6gyr, PDBe:6gyr, PDBj:6gyr
• PDBsum: 6gyr
• PubMed: 30323286
• UniProt: Q09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)