Structure of PDB 6gyo Chain A

Receptor sequence
>6gyoA (length=501) Species: 9606 (Homo sapiens) [Search protein sequence]
MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRF
YWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLN
FRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRI
DSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLAS
AVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGK
QYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHA
TALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKM
FDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRF
EVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICL
LTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDR
I
3D structure
PDB6gyo Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A F658 G659 E660 I661 C662 R669 T670 A671 R710 R713 F445 G446 E447 I448 C449 R456 T457 A458 R497 R500
BS02 PIE A N227 F229 D260 F263 Y264 I404 F405 M407 N14 F16 D47 F50 Y51 I191 F192 M194
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gyo, PDBe:6gyo, PDBj:6gyo
PDBsum6gyo
PubMed
UniProtQ9Y3Q4|HCN4_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Gene Name=HCN4)

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