Structure of PDB 6gxy Chain A

Receptor sequence
>6gxyA (length=145) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
MGSGLAKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRGFTPV
LAEFYEKHHVAKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTVSE
LGKTFGVESIPTLITINADTGAIIGTQARTRVIEDPDGANFPWPN
3D structure
PDB6gxy Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FFN A W39 C40 W70 V106 E107 S108 I109 W40 C41 W71 V107 E108 S109 I110 PDBbind-CN: -logKd/Ki=5.24,Kd=5.7uM
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gxy, PDBe:6gxy, PDBj:6gxy
PDBsum6gxy
PubMed30605929
UniProtO77404|TYPX_TRYBB Tryparedoxin

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