Structure of PDB 6gx1 Chain A

Receptor sequence
>6gx1A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
EFMVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFR
LQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVP
RVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCV
DVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDE
GDFYYGGAFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYL
LRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVP
3D structure
PDB6gx1 Blood group synthase AAGlyB in complex with UDP-GalNAc and cryoprotected with PEG 3350
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H233 G266 W300 E303 A343
Catalytic site (residue number reindexed from 1) H173 G206 W240 E243 A283
Enzyme Commision number 2.4.1.37: fucosylgalactoside 3-alpha-galactosyltransferase.
2.4.1.40: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD2 A F121 I123 Y126 W181 V184 R188 D211 V212 D213 W300 F61 I63 Y66 W121 V124 R128 D151 V152 D153 W240
BS02 UDP A F121 I123 Y126 V184 R188 D211 V212 D213 F61 I63 Y66 V124 R128 D151 V152 D153
Gene Ontology
Molecular Function
GO:0016758 hexosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gx1, PDBe:6gx1, PDBj:6gx1
PDBsum6gx1
PubMed
UniProtP16442|BGAT_HUMAN Histo-blood group ABO system transferase (Gene Name=ABO)

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