Structure of PDB 6gwg Chain A

Receptor sequence
>6gwgA (length=532) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
RGSHMASMEIFGKTFREGRFVLKEKNFTVEFAVEKIHLGWKISGRVKGSP
GRLEVLRTKAPEKVLVNNWQSWGPCRVVDAFSFKPPEIDPNWRYTASVVP
DVLERNLQSDYFVAEEGKVYGFLSSKIAHPFFAVEDGELVAYLEYFDVEF
DDFVPLEPLVVLEDPNTPLLLEKYAELVGMENNARVPKHTPTGWCSWYHY
FLDLTWEETLKNLKLAKNFPFEVFQIDDAYEKDIGDWLVTRGDFPSVEEM
AKVIAENGFIPGIWTAPFSVSETSDVFNEHPDWVVKENGEPKMAYRNWNK
KIYALDLSKDEVLNWLFDLFSSLRKMGYRYFKIDFLFAGAVPGERKKNIT
PIQAFRKGIETIRKAVGEDSFILGCGSPLLPAVGCVDGMRIGPDTAPFWG
EHIEDNGAPAARWALRNAITRYFMHDRFWLNDPDCLILREEKTDLTQKEK
ELYSYTCGVLDNMIIESDDLSLVRDHGKKVLKETLELLGGRPRVQNIMSE
DLRYEIVSSGTLSGNVKIVVDLNSREYHLEKE
3D structure
PDB6gwg Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.22: alpha-galactosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEK A W65 W190 Y191 D220 D221 W257 K325 D327 F328 R383 D387 W72 W197 Y198 D227 D228 W264 K332 D334 F335 R390 D394
BS02 MG A D419 D454 D426 D461
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004557 alpha-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0016139 glycoside catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gwg, PDBe:6gwg, PDBj:6gwg
PDBsum6gwg
PubMed30104598
UniProtG4FEF4|AGAL_THEMA Alpha-galactosidase (Gene Name=galA)

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