Structure of PDB 6gwf Chain A

Receptor sequence
>6gwfA (length=535) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
LVPRGSHMASMEIFGKTFREGRFVLKEKNFTVEFAVEKIHLGWKISGRVK
GSPGRLEVLRTKAPEKVLVNNWQSWGPCRVVDAFSFKPPEIDPNWRYTAS
VVPDVLERNLQSDYFVAEEGKVYGFLSSKIAHPFFAVEDGELVAYLEYFD
VEFDDFVPLEPLVVLEDPNTPLLLEKYAELVGMENNARVPKHTPTGWCSW
YHYFLDLTWEETLKNLKLAKNFPFEVFQIDDAYEKDIGDWLVTRGDFPSV
EEMAKVIAENGFIPGIWTAPFSVSETSDVFNEHPDWVVKENGEPKMAYRN
WNKKIYALDLSKDEVLNWLFDLFSSLRKMGYRYFKIDFLFAGAVPGERKK
NITPIQAFRKGIETIRKAVGEDSFILGCGSPLLPAVGCVDGMRIGPATAP
FWGEHIEDNGAPAARWALRNAITRYFMHDRFWLNDPDCLILREEKTDLTQ
KEKELYSYTCGVLDNMIIESDDLSLVRDHGKKVLKETLELLGGRPRVQNI
MSEDLRYEIVSSGTLSGNVKIVVDLNSREYHLEKE
3D structure
PDB6gwf Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.22: alpha-galactosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEQ A W65 W190 Y191 D220 D221 W257 K325 D327 F328 C368 R383 W75 W200 Y201 D230 D231 W267 K335 D337 F338 C378 R393
BS02 MG A D419 D454 D429 D464
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004557 alpha-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0016139 glycoside catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6gwf, PDBe:6gwf, PDBj:6gwf
PDBsum6gwf
PubMed30104598
UniProtG4FEF4|AGAL_THEMA Alpha-galactosidase (Gene Name=galA)

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