Structure of PDB 6gvx Chain A

Receptor sequence
>6gvxA (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
PLGSMKDYDELLKYYELHETIGTFAKVKLACHILTGEMVAIKIMDKNTDL
PRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQ
DRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDF
GLCAKPKGNKCGSLAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDD
DNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHP
WIMQDYNYPVEWQSKNPFIHLDDDCVTELRQTMEDLISLWQYDHLTATYL
LLLAKKARGKPVRLR
3D structure
PDB6gvx Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).
ChainA
Resolution2.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 N137 D150 S171
Catalytic site (residue number reindexed from 1) D131 K133 N136 D149 S163
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAK A A38 L86 E87 C89 P90 G91 L139 A40 L85 E86 C88 P89 G90 L138 MOAD: Ki=24nM
PDBbind-CN: -logKd/Ki=7.62,Ki=24nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6gvx, PDBe:6gvx, PDBj:6gvx
PDBsum6gvx
PubMed31108049
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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