Structure of PDB 6gvf Chain A

Receptor sequence
>6gvfA (length=910) Species: 9606 (Homo sapiens) [Search protein sequence]
NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDL
NSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQK
YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCG
CDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPS
YSRRTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCD
NVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEH
CPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKE
TPCLELEFDWFSSVVKFPDMSVIEEHANWSVSYSHAGLSNRLARDNELRE
NDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWN
SRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTD
DKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEM
HNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKD
ETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSA
KRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQ
NQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCNSHTLHQWLKDKN
KGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFG
HFLDHKKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAI
RQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMK
QMNDAHHGGW
3D structure
PDB6gvf Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE5 A D810 Y836 I848 E849 V850 V851 M922 D933 D685 Y711 I723 E724 V725 V726 M787 D798 MOAD: Ki=28nM
PDBbind-CN: -logKd/Ki=7.55,Ki=28nM
BindingDB: Kd=15nM,Ki=28nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6gvf, PDBe:6gvf, PDBj:6gvf
PDBsum6gvf
PubMed31749911
UniProtP42336|PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Gene Name=PIK3CA)

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