Structure of PDB 6gr9 Chain A

Receptor sequence
>6gr9A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEH
QLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSD
KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG
WSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGY
PPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQ
ILKHPWVQAHSRRVLPPCA
3D structure
PDB6gr9 AURKC INCENP complex bound to BRD-7880
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D166 K168 E170 N171 D184 T202
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VX6 A G50 F54 A70 E121 Y122 A123 P124 G126 L173 A183 G14 F18 A34 E85 Y86 A87 P88 G90 L137 A147 BindingDB: Ki=4.6nM,Kd=6.3nM,IC50=25nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6gr9, PDBe:6gr9, PDBj:6gr9
PDBsum6gr9
PubMed
UniProtQ9UQB9|AURKC_HUMAN Aurora kinase C (Gene Name=AURKC)

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