Structure of PDB 6gr8 Chain A

Receptor sequence
>6gr8A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
GANSRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEK
EGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKE
LQKSDKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVK
IADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYE
LLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLER
LPLAQILKHPWVQAHSRRVLPP
3D structure
PDB6gr8 AURKC INCENP complex bound to BRD-7880
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D166 K168 E170 N171 D184 T202
Catalytic site (residue number reindexed from 1) D135 K137 E139 N140 D153 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F8Z A L49 K51 G52 K53 V57 A70 K72 L74 I79 Q87 L88 E91 L118 A123 E127 E170 L173 A183 D184 G186 L18 K20 G21 K22 V26 A39 K41 L43 I48 Q56 L57 E60 L87 A92 E96 E139 L142 A152 D153 G155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gr8, PDBe:6gr8, PDBj:6gr8
PDBsum6gr8
PubMed
UniProtQ9UQB9|AURKC_HUMAN Aurora kinase C (Gene Name=AURKC)

[Back to BioLiP]