Structure of PDB 6go6 Chain A

Receptor sequence

>6go6A (length=359) Species: 10090 (Mus musculus)

KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYHQYHRSHLADSAHNLRQRSS
TMDVFERSFCILKLDHGRVHSEEGKGWKAIRVDLVMCPYDRRAFALLGWT
GSRQFERDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLD
YIEPWERNA

3D structure

• PDB: 6go6 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction.
• Chain: A
• Resolution: 2.09 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.31: DNA nucleotidylexotransferase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.11.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	L189 N391 L392 R393 Q394 R455 R459 R462 R463 T466 H467 M472 R481	L42 N244 L245 R246 Q247 R303 R307 R310 R311 T314 H315 M320 R329
BS02	dna	A	Q152 G186 S187 A190 G218 K220 V221	Q5 G39 S40 A43 G71 K73 V74
BS03	MG	A	D343 D345	D196 D198
BS04	DCT	A	G332 G333 R336 H342 D343 D345 A389 L392 G453 R455	G185 G186 R189 H195 D196 D198 A242 L245 G301 R303

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6go6, PDBe:6go6, PDBj:6go6
• PDBsum: 6go6
• PubMed: 31138645
• UniProt: P09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt);
  Q9JIW4|DPOLM_MOUSE DNA-directed DNA/RNA polymerase mu (Gene Name=Polm)