Structure of PDB 6gmh Chain A

Receptor sequence
>6gmhA (length=1441) Species: 9823 (Sus scrofa) [Search protein sequence]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVLPVPPLSVRPAVVMQRNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRV
RGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNID
RLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHM
CDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDE
MNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTK
RDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAG
SLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQ
DIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARD
KTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPF
GFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDT
AVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQN
ELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRL
PSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLC
SRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPAT
QMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARD
AERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWL
LRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRI
MNDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGE
FKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKA
LERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPL
MKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDA
EKCKYGMEIPGATPAYGAWSPSVGSGMTPGAAGFSPSAASD
3D structure
PDB6gmh Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R190 H1417 R151 H1340
BS02 rna A R67 Q267 F431 R460 D497 D499 R57 Q220 F381 R410 D447 D449
BS03 dna A Q267 K331 K346 R351 R358 Q461 T854 A855 Y859 R1416 E1433 Q220 K281 K296 R301 R308 Q411 T804 A805 Y809 R1339 E1356
BS04 ZN A C71 H84 C61 H74
BS05 MG A D495 D497 D499 D445 D447 D449
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6gmh, PDBe:6gmh, PDBj:6gmh
PDBsum6gmh
PubMed30135578
UniProtI3LJR4

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