Structure of PDB 6gl9 Chain A

Receptor sequence
>6gl9A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSG
PDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLR
DFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEA
HVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVW
SFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLP
APPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
3D structure
PDB6gl9 Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) A138 A140 R142 N143 D156
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3W A L828 V836 A853 Y904 L905 C909 R911 R953 L956 L17 V25 A42 Y93 L94 C98 R100 R142 L145 MOAD: ic50=135nM
PDBbind-CN: -logKd/Ki=6.87,Kd=135nM
BindingDB: IC50=135nM
BS02 PHU A W1011 M1037 R1059 L1060 W1078 W200 M226 R248 L249 W267
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gl9, PDBe:6gl9, PDBj:6gl9
PDBsum6gl9
PubMed29852068
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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