Structure of PDB 6gl8 Chain A

Receptor sequence
>6gl8A (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
GSYDNREIVMKYIHYKLSQRGYEWDAGADESEVVHKTLREAGDDFSRRYR
RDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCV
ESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
3D structure
PDB6gl8 S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3Q A F104 Y108 D111 F112 M115 Q118 V133 L137 G145 R146 A149 F153 F45 Y49 D52 F53 M56 Q59 V74 L78 G86 R87 A90 F94 MOAD: Kd=0.000000064M
PDBbind-CN: -logKd/Ki=8.61,Kd=2.47nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6gl8, PDBe:6gl8, PDBj:6gl8
PDBsum6gl8
PubMed29732004
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2);
Q07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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