Structure of PDB 6gk9 Chain A

Receptor sequence
>6gk9A (length=424) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
HMLRISQEALTFDDVLLIPGYSEVLPKDVSLKTRLTRGIELNIPLVSAAM
DTVTEARLAIAMAQEGGIGIIHKNMGIEQQAAEVRKVKKHETAIVRDPVT
VTPSTKIIELLQMAREYGFSGFPVVEQGELVGIVTGRDLRDTVAAIMTPK
DKLVTAREGTPLEEMKAKLYENRIEKMLVVDENFYLRGLVTFRDIEKAKT
YPLASKDEQGRLRVGAAVGTGADTGERVAALVAAGVDVVVVDTAHGHSKG
VIERVRWVKQTFPDVQVIGGNIATAEAAKALAEAGADAVKVGIGPGSCTT
RIVAGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLAKAMVAGAYC
VMMGSMFAGTEEAPGEIELFQGRSYKSYRVPYKGALSAIVHQLMGGLRAA
MGYTGSADIQQMRTQPQFVRITGA
3D structure
PDB6gk9 First-in-class allosteric inhibitors of bacterial IMPDHs.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F2K A G120 I132 V159 I179 K181 G121 I133 V154 I174 K176 BindingDB: IC50=4000nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6gk9, PDBe:6gk9, PDBj:6gk9
PDBsum6gk9
PubMed30769241
UniProtQ9HXM5

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