Structure of PDB 6gjs Chain A

Receptor sequence
>6gjsA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTTTEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSL
LMMIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRY
RSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD
LYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKIL
ILHEGSSYFYGTFSELQNL
3D structure
PDB6gjs Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T48 Q76
BS02 ATP A W401 V440 T460 G461 G463 K464 T465 S466 Q493 W16 V23 T43 G44 G46 K47 T48 S49 Q76
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6gjs, PDBe:6gjs, PDBj:6gjs
PDBsum6gjs
PubMed31201318
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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