Structure of PDB 6gj7 Chain A

Receptor sequence
>6gj7A (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKH
3D structure
PDB6gj7 Drugging an undruggable pocket on KRAS.
ChainA
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S17 T35
BS02 F0B A K5 V7 E37 S39 D54 L56 Q70 Y71 T74 G75 K5 V7 E37 S39 D54 L56 Q70 Y71 T74 G75 PDBbind-CN: -logKd/Ki=6.06,IC50=0.87uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gj7, PDBe:6gj7, PDBj:6gj7
PDBsum6gj7
PubMed31332011
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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