Structure of PDB 6gj6 Chain A

Receptor sequence
>6gj6A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVK
DSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDD
AFYTLVREIRKHK
3D structure
PDB6gj6 Drugging an undruggable pocket on KRAS.
ChainA
Resolution1.761 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S17 T35
BS02 EZZ A K5 L6 V7 E37 D54 L56 Y71 T74 G75 K5 L6 V7 E37 D54 L56 Y67 T70 G71 MOAD: Kd=20.4uM
PDBbind-CN: -logKd/Ki=4.70,Kd=20uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6gj6, PDBe:6gj6, PDBj:6gj6
PDBsum6gj6
PubMed31332011
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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