Structure of PDB 6ghx Chain A

Receptor sequence
>6ghxA (length=316) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTL
PGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAI
RSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTD
YTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGD
SLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTH
YGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTS
QEVASVKQAFDAVGVK
3D structure
PDB6ghx Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
ChainA
Resolution1.156 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H142 E143 H146 Y157 E166 D226 H231
Catalytic site (residue number reindexed from 1) H142 E143 H146 Y157 E166 D226 H231
Enzyme Commision number 3.4.24.27: thermolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D57 D59 Q61 D57 D59 Q61
BS02 CA A D138 E177 D185 E187 E190 D138 E177 D185 E187 E190
BS03 CA A E177 N183 D185 E190 E177 N183 D185 E190
BS04 CA A Y193 T194 I197 D200 Y193 T194 I197 D200
BS05 ILE A N112 H142 E143 L202 R203 N112 H142 E143 L202 R203
BS06 ILE A N112 L202 H231 N112 L202 H231
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ghx, PDBe:6ghx, PDBj:6ghx
PDBsum6ghx
PubMed30403288
UniProtP43133|THER_GEOSE Thermolysin (Gene Name=nprS)

[Back to BioLiP]