Structure of PDB 6ghj Chain A

Receptor sequence

>6ghjA (length=457) Species: 264199 (Streptococcus thermophilus LMG 18311)

GKTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRA
TAASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLAL
PFGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFG
INLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPH
YLRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLT
IVAIAIPVFYFAWMISSHLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAA
ERVDSSWFPVSWFQSLNPLFIMLYTPFFAWLWTAWPSSPTKFAVGLMFAG
LSFLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVGLSVTTKLS
QMMSMWFLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFL
SKRIQGL

3D structure

• PDB: 6ghj Tripeptide binding in a proton-dependent oligopeptide transporter.
• Chain: A
• Resolution: 2.26 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R26 Y30 Y68 K126 W296 E299 N328 E400	R22 Y26 Y64 K122 W285 E288 N317 E385
BS02	78N	A	L369 I373 A376 V451 S455	L354 I358 A361 V430 S434
BS03	78N	A	Y378 W388	Y363 W373
BS04	78M	A	L370 S385 L387 W388 L398	L355 S370 L372 W373 L383
BS05	78N	A	F319 W323 F324 P386	F308 W312 F313 P371
BS06	78N	A	M66 F112 L253	M62 F108 L249
BS07	78N	A	F231 N244 Y249	F227 N240 Y245
BS08	78N	A	W243 A248 N251 I255	W239 A244 N247 I251
BS09	78N	A	F89 Y194 L206	F85 Y190 L202
BS10	78N	A	V469 F470 S472 K473	V448 F449 S451 K452

Gene Ontology

Molecular Function

• GO:0022857 transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0006857 oligopeptide transport
• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6ghj, PDBe:6ghj, PDBj:6ghj
• PDBsum: 6ghj
• PubMed: 30194725
• UniProt: Q5M4H8