Structure of PDB 6gha Chain A

Receptor sequence
>6ghaA (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
EQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLG
MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPELLAFLLDGLHE
DLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKS
TLVCPECAKISVTFDPFCYLTLPLASKVKLKDCIELFTTKEKLGAEDPWY
CPNCKEHQQATKKLDLWSLPPVLVVHLKRFSDKLDTLVDFPINDLDMSEF
LINPNAGPCRYNLIAVSNHYGGGGHYTAFAKNKDDGKWYYFDDSSVSTAS
EDQIVSKAAYVLFYQRQDTFSGTGF
3D structure
PDB6gha The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C419 C422 C780 C154 C157 C201
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6gha, PDBe:6gha, PDBj:6gha
PDBsum6gha
PubMed30228188
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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