Structure of PDB 6gh9 Chain A

Receptor sequence
>6gh9A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
MEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPL
GMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQQELLAFLLDG
LHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGL
FKSTLVCPECAKISVTFDPFCYLTLPLASKVKLKDCIELFTTKEKLGAED
PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSDKLDTLVDFPINDLDM
SEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSS
VSTASEDQIVSKAAYVLFYQRQDTFSGTGFF
3D structure
PDB6gh9 The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C419 C422 C780 C157 C160 C204
BS02 MIX A Y855 G856 H862 Y273 G274 H280 PDBbind-CN: -logKd/Ki=4.48,IC50=33uM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6gh9, PDBe:6gh9, PDBj:6gh9
PDBsum6gh9
PubMed30228188
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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