Structure of PDB 6ggn Chain A

Receptor sequence
>6ggnA (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB6ggn In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EYH A L54 G58 I61 M62 Y67 Q72 F86 V93 H96 I99 Y100 L37 G41 I44 M45 Y50 Q55 F69 V76 H79 I82 Y83 MOAD: ic50=0.08nM
PDBbind-CN: -logKd/Ki=10.10,IC50=0.08nM
BindingDB: IC50=0.17nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6ggn, PDBe:6ggn, PDBj:6ggn
PDBsum6ggn
PubMed30217415
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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