Structure of PDB 6ggg Chain A

Receptor sequence
>6gggA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
IVYAGYDKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQIT
LIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQ
GMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKSPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESH
ALKVEFPAMLVEIISDQLPKVESGNAKPLYFHR
3D structure
PDB6ggg Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
ChainA
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 I802 M959 E962 V31 K35 L45 I49 I52 M209 E212
BS02 EYN A L766 N770 L772 A773 Q776 M807 S811 L814 F829 L848 M852 L938 F941 C942 T945 L16 N20 L22 A23 Q26 M57 S61 L64 F79 L98 M102 L188 F191 C192 T195 MOAD: Ki=0.63nM
PDBbind-CN: -logKd/Ki=9.20,Ki=0.63nM
BindingDB: IC50=20nM,Ki=0.630957nM
External links
PDB RCSB:6ggg, PDBe:6ggg, PDBj:6ggg
PDBsum6ggg
PubMed30596500
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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