Structure of PDB 6ggf Chain A

Receptor sequence
>6ggfA (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGG
MNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB6ggf A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
ChainA
Resolution1.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C176 H179 C238 C242 C81 H84 C143 C147
BS02 EXQ A L145 V147 T150 C220 E221 P222 P223 D228 L50 V52 T55 C125 E126 P127 P128 D133 PDBbind-CN: -logKd/Ki=5.39,Kd=4.1uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ggf, PDBe:6ggf, PDBj:6ggf
PDBsum6ggf
PubMed31633398
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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