Structure of PDB 6gew Chain A

Receptor sequence

>6gewA (length=376) Species: 72120 (Omphalotus olearius)

TKAGSLTIVGTGIESIGQMTLQALSYIEAAAKVFYCVIDPATEAFILTKN
KNCVDLFQYYDNGKSRLNTYTQMSELMVREVRKGLDVVGVFYGHPGVFVN
PSHRALAIAKSEGYRARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFL
IRDRPVSIHSHLVLFQVGCVGIADFNFTGFDNNKFGVLVDRLEQEYGAEH
PVVHYIAAMMPHQDPVTDKYTVAQLREPEIAKRVGGVSTFYIPPKARKAS
NLDIIRRLELRIYPANQWEPDVPEVEPYRPSDQAAIAQLADHAPPEQYQP
LATSKAMSDVMTKLALDPKALADYKADHRAFAQSVPDLTPQERAALELGD
SWAIRCAMKNMPSSLLDFPWVIVVGV

3D structure

• PDB: 6gew A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds.
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SAH	A	I19 Y98 G99 H100 V103 F104 S129 A130 F171 Q172 Y211 I212 A213 G242 V243 S244 T245	I13 Y92 G93 H94 V97 F98 S123 A124 F165 Q166 Y205 I206 A207 G236 V237 S238 T239
BS02	SFG	A	Y98 G99 H100 V103 F104 S129 A130 F171 Q172 I212 A213 G242 V243 S244 T245	Y92 G93 H94 V97 F98 S123 A124 F165 Q166 I206 A207 G236 V237 S238 T239

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

Biological Process

• GO:0032259 methylation

External links

• PDB: RCSB:6gew, PDBe:6gew, PDBj:6gew
• PDBsum: 6gew
• PubMed: 30151425
• UniProt: A0A2R2JFI5|OPHMA_OMPOL Methyltransferase/ribosomally synthesized cyclic peptide omphalotin A precursor ophMA (Gene Name=ophMA)