Structure of PDB 6gev Chain A

Receptor sequence
>6gevA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
YFSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWA
KVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLV
FNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKD
GLKSQAAFEEMRTNYIKELRKMVTKSPNNSGQSWQRFYQLTKLLDSMHDL
VSDLLEFCFYTFRESKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB6gev Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
ChainA
Resolution1.54 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 M959 E962 V47 K51 L61 I65 A221 M222 E225
BS02 EWN A N770 Q776 M807 L810 S811 L814 F829 M845 F941 C942 T945 N36 Q42 M73 L76 S77 L80 F95 M111 F207 C208 T211 MOAD: Ki=1.9nM
PDBbind-CN: -logKd/Ki=8.70,Ki=2.00nM
BindingDB: IC50=63nM,Ki=2.0nM
External links
PDB RCSB:6gev, PDBe:6gev, PDBj:6gev
PDBsum6gev
PubMed30596500
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

[Back to BioLiP]