Structure of PDB 6gde Chain A

Receptor sequence
>6gdeA (length=364) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
WMLKLIVKNGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEAEIIDAK
GLIVCPGFIDIHVHLRDPGQTYKEDIESGSRCAVAGGFTTIVCMPNTNPP
IDNTTVVNYILQKSKSVGLCRVLPTGTITKGRKGKEIADFYSLKEAGCVA
FTDDGSPVMDSSVMRKALELASQLGVPIMDHCAEEIQIARDGILAQRTGG
HVHIQHVSTKLSLEIIEFFKEKGVKITCEVNPNHLLDRLALIEGVKRGII
DCFATDHAPHQTMPGIIGLQTALPSALELYRKGIISLKKLIEMFTINPAR
IIGVDLGTLKLGSPADITIFDPNKEWILNEETNLSKSRNTPLWGKVLKGK
VIYTIKDGKMVYKD
3D structure
PDB6gde Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.3: dihydroorotase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H61 H63 D153 H62 H64 D154
Gene Ontology
Molecular Function
GO:0004038 allantoinase activity
GO:0004151 dihydroorotase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0046872 metal ion binding
Biological Process
GO:0006145 purine nucleobase catabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6gde, PDBe:6gde, PDBj:6gde
PDBsum6gde
PubMed30657257
UniProtO66990|PYRC_AQUAE Dihydroorotase (Gene Name=pyrC)

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