Structure of PDB 6g9s Chain A

Receptor sequence
>6g9sA (length=538) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NRIKLVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALR
SVVDLTDDDIAAFRKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGV
EVKGYKRRYYPYGSALTHVIGYVSKINDKDVERLNNDGKLANYAATHDIG
KLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLKEVPPQAGHDIYLTLDL
KLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNLFVDGISSKDY
SALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTTLFDPG
WWQLPGSEKRYRDWKKWGHGRLNVTRSLEESADTFFYQVAYDMGIDRLSE
WMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQG
YWTATPIQMSKALMILINDGIVKVPHLLMSTAEDGKQVPWVQPHEPPVGD
IHSGYWELAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQRDHKLMT
AFAPYNNPQVAVAMILENGGAGPAVGTLMRQILDHIML
3D structure
PDB6g9s Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
ChainA
Resolution2.001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ET5 A S330 W370 S387 D389 S545 G546 T547 S274 W314 S331 D333 S489 G490 T491 PDBbind-CN: -logKd/Ki=8.00,IC50=0.01uM
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008658 penicillin binding
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0071972 peptidoglycan L,D-transpeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g9s, PDBe:6g9s, PDBj:6g9s
PDBsum6g9s
PubMed30995398
UniProtP0AD65|MRDA_ECOLI Peptidoglycan D,D-transpeptidase MrdA (Gene Name=mrdA)

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