Structure of PDB 6g9f Chain A

Receptor sequence
>6g9fA (length=539) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NRIKLVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALR
SVVDLTDDDIAAFRKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGV
EVKGYKRRYYPYGSALTHVIGYVSKINDKDVERLNNDGKLANYAATHDIG
KLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLKEVPPQAGHDIYLTLDL
KLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNLFVDGISSKDY
SALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTTLFDPG
WWQLPGSEKRYRDWKKWGHGRLNVTRSLEESADTFFYQVAYDMGIDRLSE
WMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQG
YWTATPIQMSKALMILINDGIVKVPHLLMSTAEDGKQVPWVQPHEPPVGD
IHSGYWELAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQLRDHKLM
TAFAPYNNPQVAVAMILENGGAGPAVGTLMRQILDHIML
3D structure
PDB6g9f Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXL A S330 W370 S387 D389 S545 G546 T547 S274 W314 S331 D333 S489 G490 T491 PDBbind-CN: -logKd/Ki=6.23,IC50=0.59uM
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0009252 peptidoglycan biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g9f, PDBe:6g9f, PDBj:6g9f
PDBsum6g9f
PubMed30995398
UniProtP0AD65|MRDA_ECOLI Peptidoglycan D,D-transpeptidase MrdA (Gene Name=mrdA)

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