Structure of PDB 6g98 Chain A

Receptor sequence
>6g98A (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
RVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGH
SVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEI
HVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVM
LSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
3D structure
PDB6g98 Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.
ChainA
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1) H50 H76 H78 E88 H101 T182
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H94 H96 H119 H76 H78 H101
BS02 ER5 A R60 N62 H64 Q67 Q92 H94 H96 V121 V131 L198 T199 T200 R46 N48 H50 Q53 Q74 H76 H78 V103 V112 L181 T182 T183 MOAD: Kd=0.16nM
PDBbind-CN: -logKd/Ki=6.15,Kd=710nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6g98, PDBe:6g98, PDBj:6g98
PDBsum6g98
PubMed29928486
UniProtQ16790|CAH9_HUMAN Carbonic anhydrase 9 (Gene Name=CA9)

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