Structure of PDB 6g78 Chain A

Receptor sequence
>6g78A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQ
LYAMKVLKKASLKVRDDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG
DVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDE
IGHIKLTDFGLSKESVDQGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEM
LTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL
GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP
3D structure
PDB6g78 Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D198 K200 E202 N203 D216 T236
Catalytic site (residue number reindexed from 1) D140 K142 E144 N145 D158 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A Q81 G82 S83 F84 V87 A103 K105 D153 L155 K200 L205 T215 K221 Q31 G32 S33 F34 V37 A53 K55 D95 L97 K142 L147 T157 K163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g78, PDBe:6g78, PDBj:6g78
PDBsum6g78
PubMed34261798
UniProtQ9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase alpha-6 (Gene Name=RPS6KA6)

[Back to BioLiP]