Structure of PDB 6g77 Chain A

Receptor sequence
>6g77A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQ
LYAMKVLKKASLKVRDDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG
DVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDE
IGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS
YGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLF
KRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP
3D structure
PDB6g77 Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
ChainA
Resolution2.499 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D198 K200 E202 N203 D216 T236
Catalytic site (residue number reindexed from 1) D140 K142 E144 N145 D158 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A K113 R197 C234 R247 H250 K63 R139 C176 R189 H192
BS02 ANP A G80 G82 S83 F84 V87 A103 K105 D153 L155 K200 N203 L205 T215 K221 G30 G32 S33 F34 V37 A53 K55 D95 L97 K142 N145 L147 T157 K163
BS03 ZN A C234 H250 C176 H192
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6g77, PDBe:6g77, PDBj:6g77
PDBsum6g77
PubMed34261798
UniProtQ9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase alpha-6 (Gene Name=RPS6KA6)

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