Structure of PDB 6g74 Chain A

Receptor sequence
>6g74A (length=304) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHHHHHMVDEILKLKKEKGYIILAHNFQIPELQDIADFVGDSLQLARKAM
ELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIRE
YREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPD
RNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHP
ECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDR
EFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMF
ELMG
3D structure
PDB6g74 Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.72: quinolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A F21 C81 N109 C168 V170 C254 F27 C87 N115 C174 V176 C260
BS02 PHT A H19 F21 D35 S36 N109 H193 T210 H25 F27 D41 S42 N115 H199 T216
Gene Ontology
Molecular Function
GO:0008987 quinolinate synthetase A activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019805 quinolinate biosynthetic process
GO:0034628 'de novo' NAD biosynthetic process from aspartate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g74, PDBe:6g74, PDBj:6g74
PDBsum6g74
PubMed29641168
UniProtQ9X1X7|NADA_THEMA Quinolinate synthase (Gene Name=nadA)

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