Structure of PDB 6g6y Chain A

Receptor sequence
>6g6yA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGSSRKTYTFDMV
FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSP
NEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDL
LNPSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAA
TLMNAYSSRSHSVFSVTIHMKETELVKIGKLNLVDLAGSENNINQSLLTL
GRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEE
TLSTLEYAHRAKNILNKPE
3D structure
PDB6g6y Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R26 P27 T107 G108 G110 K111 T112 F113 E118 R10 P11 T86 G87 G89 K90 T91 F92 E97 MOAD: ic50=0.74uM
BS02 EOK A E116 G117 E118 R119 W127 A133 I136 P137 Y211 E95 G96 E97 R98 W106 A112 I115 P116 Y186 MOAD: Kd=220nM
PDBbind-CN: -logKd/Ki=6.66,Kd=220nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:6g6y, PDBe:6g6y, PDBj:6g6y
PDBsum6g6y
PubMed30031975
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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