Structure of PDB 6g4z Chain A

Receptor sequence
>6g4zA (length=322) Species: 10090 (Mus musculus) [Search protein sequence]
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYRE
EVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACA
GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYY
LGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQSLL
TGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFR
GPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKV
GKALQEVGGLKSPWKGEYKEPR
3D structure
PDB6g4z Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
ChainA
Resolution2.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 K519 N522 D536 L553 T561
Catalytic site (residue number reindexed from 1) D170 K172 N175 D189 L200 T208
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ELW A R410 V416 I469 M471 L524 C535 D536 F537 R63 V69 I122 M124 L177 C188 D189 F190 PDBbind-CN: -logKd/Ki=9.77,Ki=0.17nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6g4z, PDBe:6g4z, PDBj:6g4z
PDBsum6g4z
PubMed29940120
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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