Structure of PDB 6g38 Chain A

Receptor sequence
>6g38A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
PVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLV
NGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPP
LLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSS
LATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNG
KSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDI
YRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIK
RKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6g38 Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBN A A509 F607 G608 D611 G653 L656 I686 A38 F136 G137 D140 G182 L185 I215 MOAD: Kd=239.2nM
PDBbind-CN: -logKd/Ki=6.62,Kd=239.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g38, PDBe:6g38, PDBj:6g38
PDBsum6g38
PubMed29601130
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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