Structure of PDB 6g35 Chain A

Receptor sequence
>6g35A (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAI
KIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLN
SVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGI
DLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDL
FTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKT
KCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6g35 Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EKK A I490 A509 F605 F607 G608 D611 G653 L656 I686 I30 A49 F145 F147 G148 D151 G193 L196 I226 MOAD: Kd=17.5nM
PDBbind-CN: -logKd/Ki=7.76,Kd=17.5nM
BS02 CO A C467 H477 H563 C7 H17 H103
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g35, PDBe:6g35, PDBj:6g35
PDBsum6g35
PubMed29601130
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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