Structure of PDB 6g34 Chain A

Receptor sequence
>6g34A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
PVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLV
NGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPP
LLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSS
LATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNG
KSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDI
YRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIK
RKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB6g34 Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5ID A I49 A68 F164 F166 G167 D170 G212 L215 I245 I19 A38 F134 F136 G137 D140 G182 L185 I215 MOAD: Kd=5.7nM
PDBbind-CN: -logKd/Ki=8.24,Kd=5.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g34, PDBe:6g34, PDBj:6g34
PDBsum6g34
PubMed29601130
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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