Structure of PDB 6g2x Chain A

Receptor sequence
>6g2xA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFY
GPPGCGKTLLAKAIANECQANFISIKGPELLTSEANVREIFDKARQAAPC
VLFFDELDSIAKAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAI
LRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFS
GADLTEICQRACKLAIRESIESEIRREREPVPEIRRDHFEEAMRFARRSV
SDNDIRKYEMFAQTLQQ
3D structure
PDB6g2x Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding.
ChainA
Resolution2.078 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJQ A R625 P626 D627 D751 K754 Y755 R142 P143 D144 D254 K257 Y258
BS02 EJQ A K754 M757 F758 T761 L762 K257 M260 F261 T264 L265
BS03 ADP A I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 I12 G13 G54 C55 G56 K57 T58 L59 I173 G201 A202 T205
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6g2x, PDBe:6g2x, PDBj:6g2x
PDBsum6g2x
PubMed31701538
UniProtP55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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