Structure of PDB 6g2m Chain A

Receptor sequence
>6g2mA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SNARALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQ
YGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICT
SPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB6g2m Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases
ChainA
Resolution1.37 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D11 D13 D146
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O84 A D41 D43 F49 F75 W76 V77 W96 S131 I133 K134 R163 K165 D11 D13 F19 F45 W46 V47 W66 S101 I103 K104 R133 K135 PDBbind-CN: -logKd/Ki=7.82,Ki=15.1nM
BS02 MG A D41 D43 D176 D11 D13 D146
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g2m, PDBe:6g2m, PDBj:6g2m
PDBsum6g2m
PubMed
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

[Back to BioLiP]