Structure of PDB 6g2l Chain A

Receptor sequence
>6g2lA (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
SNAGRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSE
QYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFIC
TSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPD
ITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB6g2l Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases
ChainA
Resolution1.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D12 D14 D147
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D41 D43 D176 D12 D14 D147
BS02 EJ8 A D41 D43 F49 F75 W76 V77 W96 S131 I133 K134 R163 K165 D12 D14 F20 F46 W47 V48 W67 S102 I104 K105 R134 K136 PDBbind-CN: -logKd/Ki=7.17,Ki=68nM
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6g2l, PDBe:6g2l, PDBj:6g2l
PDBsum6g2l
PubMed
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

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