Structure of PDB 6g2c Chain A

Receptor sequence
>6g2cA (length=121) Species: 9606 (Homo sapiens) [Search protein sequence]
VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSN
QPERAWVHEKRVREYKGHKQYEELLAEQKIRKPRPQRERAQWDIGIAHAE
KALKMTREERIEQYTFIYIDK
3D structure
PDB6g2c Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EHT A V278 Y281 W284 F312 S314 Q316 E318 Q367 V13 Y16 W19 F47 S49 Q51 E53 Q91 PDBbind-CN: -logKd/Ki=4.66,Kd=22uM
External links
PDB RCSB:6g2c, PDBe:6g2c, PDBj:6g2c
PDBsum6g2c
PubMed31285596
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

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