Structure of PDB 6g27 Chain A

Receptor sequence
>6g27A (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSN
QPERAWVHEKRVREYKGHKQYEELLAEKIRKPRPQRERAQWDIGIAHAEK
ALKMTREERIEQYTFIYID
3D structure
PDB6g27 Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EHE A V278 Y281 W284 F312 S314 E318 R319 V13 Y16 W19 F47 S49 E53 R54 PDBbind-CN: -logKd/Ki=3.14,Kd=731uM
External links
PDB RCSB:6g27, PDBe:6g27, PDBj:6g27
PDBsum6g27
PubMed31285596
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

[Back to BioLiP]