Structure of PDB 6g22 Chain A

Receptor sequence
>6g22A (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
ALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRL
RPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIK
MFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAE
PTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB6g22 Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D41 D43 D176
Catalytic site (residue number reindexed from 1) D7 D9 D142
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D41 D43 D176 D7 D9 D142
BS02 2O2 A D43 F49 F75 W76 V77 W96 S131 I133 K134 R163 D9 F15 F41 W42 V43 W62 S97 I99 K100 R129 PDBbind-CN: -logKd/Ki=7.56,Ki=27.7nM
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6g22, PDBe:6g22, PDBj:6g22
PDBsum6g22
PubMed
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

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